Infergen

 

INFERGEN® (interferon alfacon-1), also known as consensus interferon, is marketed for the treatment of adults with chronic hepatitis C virus (HCV) infections. It is currently the only FDA approved, bio-optimized interferon developed through rational drug design and the only interferon with data in the label specifically for non-responding or refractory patients. InterMune's sales force re-launched Infergen in January 2002 with an active campaign to educate U.S. hepatologists about the safe and appropriate use of Infergen, which represents new hope for the more than 50 percent of HCV patients who fail other currently available therapies.

All alpha interferons, including interferon alfacon-1, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Patients should be monitored closely with periodic clinical and laboratory evaluations. Patients with persistently severe or worsening symptoms of these conditions should be withdrawn from therapy. In many but not all cases, these disorders resolve after stopping interferon alfacon-1 therapy. See WARNINGS, and ADVERSE REACTIONS in full prescribing information (Adobe Acrobat required).

 

   

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2008


HALT-C Study Design Flawed - May 01 08

Advocate EASL 2008 Coverage

Interferon Maintenance Therapy and Liver Disease Progression

HCV  New Drug Pipeline

MAINTENANCE THERAPY FOUND INEFFECTIVE HALT-C STUDY


 2007


DIRECT is a randomized, open-label, phase III investigational research study that will evaluate the safety and efficacy of daily administration of subcutaneous interferon alfacon-1 plus ribavirin versus no treatment in HCV patients who have not responded to previous combination therapy with pegylated interferon alfa plus ribavirin.

Is Pegylated Interferon Alfa-2a (Pegasys) plus Ribavirin Superior to High-dose Consensus Interferon (Infergen) plus Ribavirin?

The DIRECT Trial (Daily-Dose Consensus Interferon and Ribavirin: Efficacy of Combined Therapy): treatment of non-responders to previous pegylated interferon plus ribavirin: sustained virologic response data

Daily consensus interferon versus peg-interferon alfa2b with weight based ribavirin in treatment-naive patients with chronic hepatitis C genotype 1

U.S. multicenter pilot study of daily consensus interferon (infergen) plus ribavirin for “difficult-to-treat” HCV genotype 1 patients: tolerance and on-therapy virologic response.

Hepatitis C Virus (HCV) Treatment Outcomes with Consensus Interferon with or without Ribavirin in Peginterferon/Ribavirin Non-responders/Relapsers: Results from National Clinical Practice Settings

Treatment of Hepatitis C Patients with Child A and B cirrhosis with Consensus Interferon and Ribavirin in a Low Ascending Dosing Regimen Leads to Significant Viral Elimination Rates

Analysis of Relapse Rates in Pegylated Interferon and Ribavirin Non-Responders Treated With Daily Consensus Interferon and Ribavirin

Daily consensus interferon versus peg-interferon alfa2b with weight based or 800 mg ribavirin in treatment-naive patients with chronic hepatitis C genotypes 2 or 3

Treatment of Peginterferon/Ribavirin Nonresponders with daily Dosing of Consensus Interferon and Ribavirin - Preliminary Results of the German Consensus Interferon Multicenter Study

HCV Advocate’s AASLD Conference coverage

HIV and Hepatitis.com Coverage of the
58th Annual Meeting of the American Association
for the Study of Liver Diseases (AASLD 2007)

November 2-6, 2007, Boston, MA


2006 -


 

Promising Data on Consensus Interferon Retreatment of Relapsers and Non-Responders

June 06 06

Valeant Pharmaceuticals to Acquire Consensus Interferon (Infergen) from Intermune

Jan 2006

Sustained Virologic Response Rates from a Randomized Trial of HCV Genotype-1 Subjects Treated with Either Consensus IFN and Ribavirin or Pegylated Interferon alfa-2b and Ribavirin

Dec 2005

Consensus Interferon (Infergen) and Ribavirin in Nonresponders to Prior Therapy with Either Standard Interferon Alfa and Ribavirin or Pegylated Interferon and Ribavirin

Efficacy of Daily Consensus Interferon (Infergen) and Ribavirin Compared to PEG-Interferon Alfa-2b (PegIntron) and Ribavirin in Nonresponders with Chronic Hepatitis C

Consensus Interferon + IFN Gamma in PegIFN/RBV Non-Responders

June 2005

Does Retreatment with Interferon Alfacon (Infergen) Plus Interferon Gamma (Actimmune) Benefit Nonresponders to Peginterferon Plus Ribavirin?

May 28 2005

Interferon Alfacon-1 (Infergen) Alone or in Combination with IFN Gamma-1b (Actimmune) Suppresses Replication of a PEG IFN-Alfa-2b-resistant Hepatitis C Virus Replicon

May 28 2005

High Dose Consensus Interferon (Infergen) and Ribavirin Is Effective for Patients with Chronic Hepatitis B Who Have Failed on Peginterferon and Ribavirin

May 28 2005

Efficacy of Daily Consensus Interferon (Infergen) and Ribavirin Compared to Peg-Interferon Alfa2b (PegIntron) and Ribavirin in Treatment-Naive Patients with HCV Genotype 2 or 3

Consensus Interferon for Peg/RBV Nonresponders

Nov 11 2004

Comparison of Black and Nonblack Nonresponders Treated With Interferon alfacon-1 Plus Ribavirin

Nov 11 2004


 

Consensus Interferon Study for Peginterferon Nonresponders: 41 study sites

Enrollment Open for Phase III Trial of Daily Consensus Interferon (Infergen) Plus Ribavirin for HCV Treatment Nonresponders

Sep 2004

Combination Interferon Therapy: Infergen plus Actimmune
 

  Infergen Plus Actimmune Shows Promise in Nonresponders
  Potential HCV Therapy Shows Positive Results In Ongoing Pilot Study
  Daily High-Dose Infergen Treatment Clears Hepatitis C Virus Better than Standard Dosing
  InterMune Announces Phase IV Study Shows Infergen Combination Therapy More Effective Than Rebetron for Hepatitis C
  Infergen Patient Assistance Program

 

   
   

 

 
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