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Drug Updates: Telaprevir or BoceprevirNewsWhats Up ?Vertex Has Begun Telaprevir FDA ApplicationJuly News Summary On New Oral InhibitorsData from two more phase III trials is expected in the next couple of months. The remaining results from the Illuminate trial are expected in August and the Realize trial in September.
Drug Updates:
Telaprevir or Boceprevir
News
Whats Up ?
Vertex Has Begun Telaprevir FDA Application
July News Summary On New Oral Inhibitors
Data from two more phase III trials is expected in the next couple of months. The remaining results from the Illuminate trial are expected in August and the Realize trial in September.
Facts and FiguresHepatitis C Is More Common than HIV.It is estimated that about 4.1 million people in the United States are infected with hepatitis C, which is about 1.8% of the population. This makes hepatitis C much more common than HIV infection. Today about 3.2 million Americans have chronic hepatitis C infection, which means they cannot get rid of the virus on their own. The number of people at risk for chronic liver disease is expected to increase as much as four times by 2015. Each year, there are about 36,000 new cases of acute hepatitis C.Groups at Highest Risk for HCV.Hepatitis C prevalence is highest among those with large or repeated exposures to blood such as intravenous (IV) drug users, hemophiliacs treated with clotting factor concentrates produced prior to 1987; and recipients of transfusions or organs, or both, from HCV-positive donors. Most (65%) HCV infections are transmitted by intravenous drug use. Studies of prison inmates, military veterans and homeless men have confirmed injection drug use as the most common risk factor for HCV infection. Veterans are at higher risk for hepatitis CSeveral studies suggest veterans have a higher prevalence of hepatitis C virus infection than nonveterans. In a study with randomly selected veterans, significant predictors of HCV infection included demographic factors, period of military service (for example, Vietnam era), prior diagnoses, health care use, and lifestyle factors. The prevalence of hepatitis C among the veterans in this survey exceeded the estimate from the general US population by more than twofold.If you are a veteran and think you might be at risk for hepatitis C, ask your doctor about being tested for hepatitis C. In some cases, the diagnosis can be related to military duty, and treatment may be covered by Veterans Administration benefits.Hemophiliacs have higher risk factorHemophiliacs are at higher risk than the general population for all blood borne infections because they regularly receive blood transfusions and blood products such as clotting factor. However, in 1987, a process to inactivate viruses such as HCV was introduced. In addition, screening for hepatitis C antibodies began in US blood banks in 1990, and continued to improve throughout the decade, with nucleic acid amplification (NAT) screening instituted in 1999. Altogether, these measures dramatically decreased the probability of blood or blood products as a potential source of HCV infection. However, hemophiliacs who received a transfusion or factor concentrate before 1987 may be at higher risk.Homeless can be at risk for hepatitis CHomeless people can be at risk for multiple health problems, including hepatitis C. It is suggested that this is because of the prevalence of certain behaviors among members of this population, such as injection drug use, and the sharing of equipment related to drug use. Studies have shown significantly higher rates of HCV infection among the homeless.Inmates are at risk for hepatitis CThe rate of hepatitis C infection is higher in the prison population than in the general population, with estimates ranging from 13% to 54%. This statistic is probably because injection drug use is very common among those who are in prison. And 70% to 80% of those currently in prison admit to having used illegal drugs.HIV and hepatitis CAbout one quarter of people with HIV (the virus that causes AIDS), primarily those who acquired HIV through injection drug use or through a blood transfusion, are also infected with the hepatitis C virus. Because hepatitis C infection can become serious very quickly in HIV-positive people, they should be tested for HCV.
Facts and Figures
Hepatitis C Is More Common than HIV.
It is estimated that about 4.1 million people in the United States are infected with hepatitis C, which is about 1.8% of the population. This makes hepatitis C much more common than HIV infection. Today about 3.2 million Americans have chronic hepatitis C infection, which means they cannot get rid of the virus on their own. The number of people at risk for chronic liver disease is expected to increase as much as four times by 2015. Each year, there are about 36,000 new cases of acute hepatitis C.
Groups at Highest Risk for HCV.
Hepatitis C prevalence is highest among those with large or repeated exposures to blood such as intravenous (IV) drug users, hemophiliacs treated with clotting factor concentrates produced prior to 1987; and recipients of transfusions or organs, or both, from HCV-positive donors. Most (65%) HCV infections are transmitted by intravenous drug use. Studies of prison inmates, military veterans and homeless men have confirmed injection drug use as the most common risk factor for HCV infection.
Veterans are at higher risk for hepatitis C
Several studies suggest veterans have a higher prevalence of hepatitis C virus infection than nonveterans. In a study with randomly selected veterans, significant predictors of HCV infection included demographic factors, period of military service (for example, Vietnam era), prior diagnoses, health care use, and lifestyle factors. The prevalence of hepatitis C among the veterans in this survey exceeded the estimate from the general US population by more than twofold.
If you are a veteran and think you might be at risk for hepatitis C, ask your doctor about being tested for hepatitis C. In some cases, the diagnosis can be related to military duty, and treatment may be covered by Veterans Administration benefits.
Hemophiliacs have higher risk factor
Hemophiliacs are at higher risk than the general population for all blood borne infections because they regularly receive blood transfusions and blood products such as clotting factor. However, in 1987, a process to inactivate viruses such as HCV was introduced. In addition, screening for hepatitis C antibodies began in US blood banks in 1990, and continued to improve throughout the decade, with nucleic acid amplification (NAT) screening instituted in 1999. Altogether, these measures dramatically decreased the probability of blood or blood products as a potential source of HCV infection. However, hemophiliacs who received a transfusion or factor concentrate before 1987 may be at higher risk.
Homeless can be at risk for hepatitis C
Homeless people can be at risk for multiple health problems, including hepatitis C. It is suggested that this is because of the prevalence of certain behaviors among members of this population, such as injection drug use, and the sharing of equipment related to drug use. Studies have shown significantly higher rates of HCV infection among the homeless.
Inmates are at risk for hepatitis C
The rate of hepatitis C infection is higher in the prison population than in the general population, with estimates ranging from 13% to 54%. This statistic is probably because injection drug use is very common among those who are in prison. And 70% to 80% of those currently in prison admit to having used illegal drugs.
HIV and hepatitis C
About one quarter of people with HIV (the virus that causes AIDS), primarily those who acquired HIV through injection drug use or through a blood transfusion, are also infected with the hepatitis C virus. Because hepatitis C infection can become serious very quickly in HIV-positive people, they should be tested for HCV.
Click here to order a FREE Home Access Hepatitis C Test KitHow Soon Should I Get Tested After Exposure ? After the exposure (especially if the blood exposure involved another person known to have the hepatitis C virus), it is recommended that testing for the hepatitis C antibody be performed at 4 to 6 months after the exposure OR that testing for the hepatitis C virus itself (a test often called an HCV PCR or hepatitis C viral load test) be performed 4 to 6 weeks after the potential exposure. These tests are done to determine whether or not hepatitis C infection has occurred as a result of the exposure.
Click here to order a FREE Home Access Hepatitis C Test Kit
How Soon Should I Get Tested After Exposure ?
After the exposure (especially if the blood exposure involved another person known to have the hepatitis C virus), it is recommended that testing for the hepatitis C antibody be performed at 4 to 6 months after the exposure OR that testing for the hepatitis C virus itself (a test often called an HCV PCR or hepatitis C viral load test) be performed 4 to 6 weeks after the potential exposure. These tests are done to determine whether or not hepatitis C infection has occurred as a result of the exposure.
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HCV and Liver Heatlh
Telaprevir / Boceprevir
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New Drug Updates: Telaprevir or BoceprevirBMS-790052RG7128TMC435Hepatitis C Treatments in Current Clinical Development
New Drug Updates:
BMS-790052
RG7128
TMC435
Hepatitis C Treatments in Current Clinical Development
"The Hepatitis C Digest"Test Results In HCV Infection
"The Hepatitis C Digest"
Test Results In HCV Infection
Introduction to liver blood testsLiver function tests generally refer to a group of blood tests that measure certain enzymes or proteins in your blood. Liver function tests are used to help detect, evaluate and monitor liver disease or damage. The term "liver function tests" can be misleading, because not all of these tests actually measure liver function. Some tests, such as albumin and bilirubin, do. These liver function tests measure how well the liver is producing the protein albumin and clearing a blood waste product, bilirubin. Other tests commonly done, but not true "liver function" tests, measure enzymes that liver cells release in response to damage or disease.
Introduction to liver blood tests
Liver function tests generally refer to a group of blood tests that measure certain enzymes or proteins in your blood. Liver function tests are used to help detect, evaluate and monitor liver disease or damage.
The term "liver function tests" can be misleading, because not all of these tests actually measure liver function. Some tests, such as albumin and bilirubin, do. These liver function tests measure how well the liver is producing the protein albumin and clearing a blood waste product, bilirubin. Other tests commonly done, but not true "liver function" tests, measure enzymes that liver cells release in response to damage or disease.
Find The Answers
Comprehensive list of HCV frequently asked questionsHCV New and Old TherapiesTrials and Financial Help
Comprehensive list of HCV frequently asked questions
HCV New and Old Therapies
Trials and Financial Help
Newly diagnosed ?
Help with taking those first stepsFrom information about disease progression to your first blood testsThe entries on this blog are oftenedited with updated and accurateinformation Just like this virus the research is continually evolving Check back often to keep updated
Help with taking those first steps
From information about disease progression to your first blood tests
The entries on this blog are often
edited with updated and accurate
information
Just like this virus the research is
continually evolving
Check back often to keep updated
What Does The Liver Do?
Your Liver FunctionsThe characteristic structure and organization of the liver enables it to perform vital roles in regulating, synthesizing, storing, secreting, transforming, and breaking down many different substances in the body. In addition, the liver's ability to regenerate lost tissue helps maintain these functions, even in the face of moderate damage. This section of the module focuses on the structural aspects of the liver and its ability to regenerate.
Your Liver Functions
The characteristic structure and organization of the liver enables it to perform vital roles in regulating, synthesizing, storing, secreting, transforming, and breaking down many different substances in the body. In addition, the liver's ability to regenerate lost tissue helps maintain these functions, even in the face of moderate damage. This section of the module focuses on the structural aspects of the liver and its ability to regenerate.
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